WPATH aim to establish the world best practice treatment for trans people in their Standards of Care - Eighth Edition (SOC-8).[]

Hormone Replacement Therapy

WPATH recommend beginning hormone suppression and replacement on the first physical signs of puberty (Tanner Stage 2).[: Statements 12.1, 12.5] Hormone suppression should be done through the use of GnRH blockers in the first instance.[: Statement 12.2] They support the argument that such treatments may be undertaken by primary care physicians (General Practitioners, or GPs, in the UK).[: p. S144]

Their eligibility criteria boils down to:[: Appendix D]

  1. Clear gender incongruence, meeting the relevant diagnostic criteria,
  2. Informed consent, taking into account the risks and benefits, and
  3. Having reached Tanner Stage 2.

Surgery

WPATH recommend offering gonadectomies (removal of gonads) after six months of hormone treatment (where the person wishes to have hormone treatment).[: Statement 13.5] As for other “gender-affirming genital procedures”, they recommend waiting until a patient is stable on their current medical treatment (where there is other medical treatment).[: Statement 13.6]

The eligibility criteria for surgery is essentially similar to that for HRT, except for adolescents who wish to have some form of hormone therapy, who should have been on these hormones for twelve months.[: Appendix D]

References

Show: None, Only Cited, All.

  1. IESOGI, “Mandate of the Independent Expert on protection against violence and discrimination based on sexual orientation and gender identity” (OL GBR 15/2022, 13 December 2022).
  2. United Nations High Commissioner for Human Rights, “Living Free and Equal” (October 2016).
  3. Lemkin Institute, “Red Flag Alert on Anti-Trans and Intersex Rights in the UK” (30 June 2025).
  4. IESOGI, “Reports on Gender: The Law of Inclusion & Practices of Exclusion” (2021).
  5. IESOGI, “Protection against violence and discrimination based on sexual orientation and gender identity” (A/73/152, 12 July 2018).
  6. Parliamentary Assembly Resolution 2048 (2015), “Discrimination against transgender people in Europe” (adopted 22 April 2015).
  7. Fourat Ben Chikha, explanatory memorandum to “Combating rising hate against LGBTI people in Europe” (Committee on Equality and Non-Discrimination, Doc. 15425, 17 December 2021).
  8. Ministry of Justice and HM Prison and Probation Service,“The care and management of individuals who are transgender” (updated 14 November 2024).
  9. Annex A to [], “Transgender prisoners – initial allocation process map”.
  10. Gov.uk, “Apply for a Gender Recognition Certificate: What documents you need”.
  11. Gender Recognition Act 2004.
  12. “Allow transgender people to self-identify their legal gender” (UK Government and Parliament Petitions).
  13. IESOGI, “Visit to the United Kingdom of Great Britain and Northern Ireland” (A/HRC/56/49/Add.1, 11 April 2024).
  14. Women and Equalities Committee, “Reform of the Gender Recognition Act” (House of Commons, HC 977, 15 December 2021).
  15. R (Castellucci) v Gender Recognition Panel [2025] EWCA Civ 167.
  16. R (Elan-Cane) v Secretary of State for the Home Department [2021] UKSC 56.
  17. Good Law Project, “Trans people must be allowed to have children” (9 July 2025).
  18. TransActual, “Gender Clinics” (4 April 2025).
  19. The Yogyakarta Principles on the Application of International Human Rights Law in relation to Sexual Orientation and Gender Identity (2006).
  20. Yogyakarta Principles plus 10 (10 November 2017).
  21. UN General Assembly, “United Nations Standard Minimum Rules for the Treatment of Prisoners (the Nelson Mandela Rules)” (A/RES/70/175, adopted 17 December 2015).
  22. Tomris Atabay et. al., “Handbook on Prisoners with special needs” (United Nations Office on Drugs and Crime, 2009).
  23. Ministry of Justice and HM Prison and Probation Service, “Searching Policy Framework” (14 April 2025).
  24. Annex A to [], “Transgender & Non-Binary Searching Considerations”.
  25. WPATH, “Standards of Care for the Health of Transgender and Gender Diverse People” (Version 8, 15 September 2022), doi: 10.1080/26895269.2022.2100644.
  26. Trans Actual, “First appointments at gender services” (29 March 2024).
  27. Department of Health and Social Care, “Puberty blockers: what you need to know” (16 May 2025).
  28. “The Cass Review: Final Report” (archived by the National Archives On 11 Mar 2025).
  29. Meredithe McNamara et al., “An Evidence-Based Critique of “The Cass Review” on Gender-affirming Care for Adolescent Gender Dysphoria” (27 August 2024).
  30. Chris Noone et al., “Critically Appraising the Cass Report: Methodological Flaws and Unsupported Claims” (10 June 2024), doi: 10.31219/osf.io/uhndk.
  31. Cal Horton, “The Cass Review: Cis-supremacy in the UK’s approach to healthcare for trans children” (14 March 2024), doi: 10.1080/26895269.2024.2328249.
  32. D. M. Grijseels, “Biological and psychosocial evidence in the Cass Review: a critical commentary” (8 June 2024), doi: 10.1080/26895269.2024.2362304.
  33. Ruth Pearce, “What’s wrong with the Cass Review? A round-up of commentary and evidence” (updated 28 June 2025).
  34. Committee of Experts on Sexual Orientation, Gender Identity and Expression, and Sex Characteristics, “Right to the highest attainable standard of health and access to healthcare for LGBTI people in Europe” (Council of Europe, September 2024).
  35. Regulation (EU) No 536/2014 of the European Parliament and of the Council of 16 April 2014 on clinical trials on medicinal products for human use (OJ L 158 27.5.2014, p. 1).
  36. NHS, “Terms of reference: Review of the NHS adult gender dysphoria clinics in England” (14 November 2024).
  37. TransActual, “Statement on the announcement of the Levy Review” (21 August 2024).